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[Using a recently established model in which apoptosis of CTCL cell lines is induced by Notch-1 inhibition by ?-secretase inhibitors (GSIs), we found that miR-122 was significantly increased in the apoptotic cells. miR-122 up-regulation was not specific for GSI-1 but was also seen during apoptosis induced by chemotherapies including doxorubicin and proteasome blockers (bortezomib, MG132). miR-122 was not expressed in quiescent T-cells, but was detectable in CTCL: in lesional skin in mycosis fungoides and in S�zary cells purified from peripheral blood.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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