. . . . . . . "[Although elevated levels of transcriptionally active CREB appear to attenuate DA transmission by increasing expression of the endogenous ? opioid receptor (KOR) ligand dynorphin, increased dynorphin transmission may ultimately have undesirable effects that contribute to drug withdrawal states as well as comorbid psychiatric illnesses such as depression.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:15:16+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .