http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14#head http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14#assertion http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14#provenance http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14#publicationInfo http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14#assertion http://rdf.disgenet.org/resource/gda/DGN1f6881b4b2bf8cb51ea6bf1c6cecc46f http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/231 http://rdf.disgenet.org/resource/gda/DGN1f6881b4b2bf8cb51ea6bf1c6cecc46f http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C0029925 http://rdf.disgenet.org/resource/gda/DGN1f6881b4b2bf8cb51ea6bf1c6cecc46f http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001123 http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14#provenance http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14#assertion http://purl.org/dc/terms/description [For these studies we have used the A2780 ovarian cancer cell line and its chemoresistant derivatives A2780/DDP and A2780/ADR, providing evidence that: (i) the three cell lines are either scarcely sensitive (A2780 and A2780/ADR) or moderately sensitive (A2780/DDP) to the cytotoxic effects of TRAIL; (ii) the elevated c-FLIP expression observed in ovarian cancer cells is a major determinant of TRAIL resistance of these cells; (iii) proteasome inhibitors (PS-341 or MG132) are able to exert a significant pro-apoptotic effect and to greatly enhance the sensitivity of both chemosensitive and chemoresistant A2780 cells to TRAIL; (iv) proteasome inhibitors damage mitochondria through stabilization of BH3-only proteins, Bax and caspase activation and significantly enhance TRAIL-R2 expression; (v) TRAIL-R2, but not TRAIL-R1, mediates the apoptotic effects of TRAIL on ovarian cancer cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14#assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14#assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/17252198 http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v5.0.0/void/BEFREE http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14#assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/ECO_0000203 http://rdf.disgenet.org/v5.0.0/void/BEFREE http://purl.org/pav/importedOn 2017-02-19 http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/ECO_0000212 http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v5.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14#publicationInfo http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://purl.org/dc/terms/created 2017-10-17T13:10:25+02:00 http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v5.0.0/void/IBIGroup http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://purl.org/pav/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://purl.org/pav/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://purl.org/pav/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://purl.org/pav/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://purl.org/pav/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://purl.org/pav/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP37438.RAESj_v47bHQWwDzc-jmMp1WgOQB-H79Yo1I4gpxpZw14 http://purl.org/pav/version v5.0.0.0 http://rdf.disgenet.org/v5.0.0/void/disgenetv3.0rdf http://purl.org/pav/version v5.0.0