. . . . . . . "[The most important development has been the discovery that loss-of-function mutations in the gene encoding the epidermal protein filaggrin increase the risk for ICD and for nickel sensitization and nickel ACD, emphasizing the importance of the skin barrier in the pathophysiology of CD.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:12:46+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .