. . . . . . . "[We found that amyloid-? peptide (A?) oligomers, synaptotoxins that accumulate in the brains of AD patients, activated the JNK/TNF-? pathway, induced IRS-1 phosphorylation at multiple serine residues, and inhibited physiological IRS-1pTyr in mature cultured hippocampal neurons.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:13:33+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .