. . . . . . . "[Together, these data suggest that apolipoprotein E4 is a co-factor that enhances the toxicity of oligomeric amyloid-? both by increasing its levels and directing it to synapses, providing a link between apolipoprotein E ?4 genotype and synapse loss, a major correlate of cognitive decline in Alzheimer's disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en . . . . . "2017-02-19"^^ . . "Gene-disease associations inferred from text-mining the literature."@en . "DisGeNET evidence - LITERATURE"@en . "2017-10-17T13:10:37+02:00"^^ . . . . . . . . . . . "v5.0.0.0" . "v5.0.0" .