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[Patients with significantly increasing sBT (sBT slope ?0.15) after 48 months of follow-up showed a slightly greater rate of development of diffuse bone sclerosis (13% vs. 2%) and hepatomegaly plus splenomegaly (16% vs. 5%), as well as a significantly greater frequency of multilineage vs. mast cells (MC)-restricted KIT mutation (p?=?0.01) together with a greater frequency of cases with progression of ISM to smouldering and aggressive SM (p?=?0.03), and a shorter progression-free survival (p?=?0.03).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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