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[We investigated the effect of endurance exercise on markers of oxidative damage (4-hydroxy-2-nonenal (4-HNE), protein carbonyls (PCs)) and antioxidant enzymes (superoxide dismutase (SOD), catalase) in skeletal muscle; urinary markers of oxidative stress (8-hydroxy-2-deoxyguanosine (8-OHdG), 8-isoprostane); and plasma cytokines (C-reactive protein (CRP), interleukin-6 (IL-6), leptin, adiponectin).Methods:Age- and fitness-matched sedentary obese and lean men (n=9 per group) underwent 3 months of moderate-intensity endurance cycling training with a vastus lateralis biopsy, 24-h urine sample and venous blood samples taken before and after the intervention.Results:Obese subjects had increased levels of oxidative damage: 4-HNE (+37%; P?0.03) and PC (+63%; P?0.02); evidence of increased adaptive response to oxidative stress because of elevated levels of copper/zinc SOD (Cu/ZnSOD) protein content (+84%; P?0.01); increased markers of inflammation: CRP (+737%; P?0.0001) and IL-6 (+85%; P?0.03), and these correlated with increased markers of obesity; and increased leptin (+262%; P?0.0001) with lower adiponectin (-27%; P?0.01) levels vs lean controls.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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